Home  >  Products  >  Fli-1a, CT (Fli-1 Protein, Friend Leukemia Integration 1, Friend Leukemia Integration 1a, fli1a, Dr.78408, CH211-241L24.8-001)
Fli-1a, CT (Fli-1 Protein, Friend Leukemia Integration 1, Friend Leukemia Integration 1a, fli1a, Dr.78408, CH211-241L24.8-001)

Fli-1a, CT (Fli-1 Protein, Friend Leukemia Integration 1, Friend Leukemia Integration 1a, fli1a, Dr.78408, CH211-241L24.8-001)

Cat no: F6230-11

Supplier: United States Biological
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Friend leukemia integration 1a (Fli-1a) is an ETS domain transcription factor. The Fli-1a zebrafish homologue has shown similarities to those in other vertebrates in aa sequence and DNA binding properties. Initial expression occurs in the posterior lateral mesoderm, within hemangioblast precursors of blood and endothelium. Fli-1a is also expressed at sites of vasculogenesis. Loss of function studies in zebrafish embryos demonstrate complete absence of hemangioblasts, indicating that Fli-1a is essential. Fli-1 acts upstream of key hemangioblast genes Gata2, Scl, Lmo2, and Etsrp, indicating its higher position in transcriptional regulatory hierarchy for hemangioblast specification in vertebrate embryos. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: F6230-11P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6230-11
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Brown, LA et al (2000) Mech. Dev. 90(2):237-252. 2. Liu, F et al (2008) Curr. Biol. 18(16):1234-1240.
Additional info: Recognizes zebrafish Fli-1a.

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