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FLII (Protein Flightless-1 Homolog, FLIL)

FLII (Protein Flightless-1 Homolog, FLIL)

Cat no: F4544-30

Supplier: United States Biological
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Flightless-1 homolog is a 1269aa containing protein with a gelsolin-like actin binding domain and an N-terminal leucine rich protein-protein interaction domain acts as a coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and in conjunction with NCOA2 and CARM1. FLIIH is involved in estrogen hormone signaling and early embryonic development. The protein also plays a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS). Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4544-30
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Sugiyama, S. et al. Dev. Growth Differ. 51:369-377 (2009). 2. Xu, J. et al. J. Biol. Chem. 284:14377-14385 (2009). 3. Ramakrishnan, R. et al. Oncogene 23:7087-7094 (2004).
Additional info: Recognizes human FLII. Species Crossreactivity: chimpanzee, equine, mouse, rat, rhesus monkey. Species sequence homology: chicken, bovine, canine.

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