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FLIP gamma/delta, CT (FLIP gamma, FLIP delta)

FLIP gamma/delta, CT (FLIP gamma, FLIP delta)

Cat no: F4550-50

Supplier: United States Biological
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FLIP interacts with the adaptor protein FADD, and with Caspase-8 (FLICE) and Caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1. FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. AHP1591 recognizes human and murine delta and gamma variants but not the alpha or beta, variants. FLIP is widely expressed in human tissues and a diverse range of cell lines. Applications: Suitable for use in Immunohistochemistry (frozen) and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 2ug/ml Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F4550-50
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Thome M., et al (1997) Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386:517-521. 2. Irmler M., et al (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388:190-195. 3. Shu H.B., et al (1997) Casper is a FADD- and caspase-related inducer of apoptosis. Immunity 6:751-763. 4. Hu S., et al (1997) I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J. Biol. Chem. 272:17255-17257.
Additional info: Recognizes human FLIP gamma/DELTA, CT. Species Crossreactivity: mouse.

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