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FLNA (Y1046) (Filamin-A, FLN-A, Alpha-filamin, Filamin-1, Endothelial Actin-binding Protein, Actin-binding Protein 280, ABP-280, Non-muscle Filamin, FLN, FLN1) (Biotin)

Cat no: F4510-79K-Biotin

FLNA (Y1046) (Filamin-A, FLN-A, Alpha-filamin, Filamin-1, Endothelial Actin-binding Protein, Actin-binding Protein 280, ABP-280, Non-muscle Filamin, FLN, FLN1) (Biotin)

Actin-binding protein 280, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:10-1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F4510-79K-Biotin

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Ravid,D., Exp. Cell Res. 314(15), 2762-2773 (2008). 2. Maceyka,M., Mol. Cell. Biol. 28(18), 5687-5697 (2008).

Additional Info

Recognizes human FLNA.

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