Flt1 (Fms-like Tyrosine Kinase 1, FLT-1, FLT, FRT, Tyrosine-protein Kinase FRT, Tyrosine-protein Kinase Receptor FLT, Vascular Endothelial Growth Factor Receptor 1, VEGFR1, VEGFR-1, Vascular Permeability Factor Receptor)

The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. It shares similar features with two other flt-family encoded proteins KDR/Flk-1 and Flt-4 and has been recently identified as a receptor for vascular endothelial growth factor (VEGF). It encodes for a 180 kD glycoprotein, binds VEGF with high affinity and undergoes autophosphorylation. It regulates cell migration through modulating actin reorganization, which is essential for cell motility. It also plays a key role in vascular development, regulation of vascular permeability and induction of proliferation of vascular endothelial cells. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. The Human frt sequence was found to be conserved in a wide variety of vertebrates. It is located on chromosome 13q12. Alternatively spliced transcript variants encoding two isoforms, Flt1 and sFlt1 have been described, with the isoform sFlt1 having an inhibitory role in angiogenesis.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nAngiosarcoma\n\nCellular Localization: \nCytoplasmic\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F4599-03H

Size

500ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Kanno et al. Oncogene 19: 2138, 2000. 2. Ahmed et al. Growth Factors 12: 235, 1995. 3. Ankam-Sey et al. Oncogene 17: 115, 1998. 4. Shibuya et al. Oncogene 5: 519, 1990. 5. Matsushime et al. Jpn J Cancer Res 78: 655, 1987. 6. Seetharam et al. Oncogene 10: 135, 1995.

Additional Info

Recognizes human FLT1. Species Crossreactivity: mouse and rat.

Alternative Names

Fms-related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor), EC=2.7.10.1