Home  >  Products  >  Flt1 (Fms-like Tyrosine Kinase 1, FLT-1, FLT, FRT, Tyrosine-protein Kinase FRT, Tyrosine-protein Kinase Receptor FLT, Vascular Endothelial Growth Factor Receptor 1, VEGFR1, VEGFR-1, Vascular Permeability Factor Receptor)
Flt1 (Fms-like Tyrosine Kinase 1, FLT-1, FLT, FRT, Tyrosine-protein Kinase FRT, Tyrosine-protein Kinase Receptor FLT, Vascular Endothelial Growth Factor Receptor 1, VEGFR1, VEGFR-1, Vascular Permeability Factor Receptor)

Flt1 (Fms-like Tyrosine Kinase 1, FLT-1, FLT, FRT, Tyrosine-protein Kinase FRT, Tyrosine-protein Kinase Receptor FLT, Vascular Endothelial Growth Factor Receptor 1, VEGFR1, VEGFR-1, Vascular Permeability Factor Receptor)

Cat no: F4599-03H

Supplier: United States Biological
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The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. It shares similar features with two other flt-family encoded proteins KDR/Flk-1 and Flt-4 and has been recently identified as a receptor for vascular endothelial growth factor (VEGF). It encodes for a 180 kD glycoprotein, binds VEGF with high affinity and undergoes autophosphorylation. It regulates cell migration through modulating actin reorganization, which is essential for cell motility. It also plays a key role in vascular development, regulation of vascular permeability and induction of proliferation of vascular endothelial cells. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. The Human frt sequence was found to be conserved in a wide variety of vertebrates. It is located on chromosome 13q12. Alternatively spliced transcript variants encoding two isoforms, Flt1 and sFlt1 have been described, with the isoform sFlt1 having an inhibitory role in angiogenesis. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Angiosarcoma Cellular Localization: Cytoplasmic Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4599-03H
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: Fms-related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor), EC=2.7.10.1
References: 1. Kanno et al. Oncogene 19: 2138, 2000. 2. Ahmed et al. Growth Factors 12: 235, 1995. 3. Ankam-Sey et al. Oncogene 17: 115, 1998. 4. Shibuya et al. Oncogene 5: 519, 1990. 5. Matsushime et al. Jpn J Cancer Res 78: 655, 1987. 6. Seetharam et al. Oncogene 10: 135, 1995.
Additional info: Recognizes human FLT1. Species Crossreactivity: mouse and rat.

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