FLT3-Ligand is a glycoprotein that functions asgrowth factor controlling the proliferation of
early hematopoietic cells and pro B-cells.FLT3-Ligand activity is mediated by binding to the transmembrane glycoprotein FLT3/FLK-2; a class III receptor tyrosine kinase (RTK). The receptor has the extracellular domain made of five Ig-like domains, one transmembrane domain and the cytoplasmic kinase domain. The biological activity is mediated when the receptor is autophosphorylated as result of binding RTK 3 ligand to the extracellular domain. FLT3-Ligand synergizes with several cytokines to stimulate the growth anddifferentiation of hematopoietic progenitors. Research suggests a role of FLT3 Ligand in cancers such as acute myeloid leukemias. Internal tandem duplications of FLT3 which cause continuous activation of the receptor are present in acute myeloid leukemia patients
Applications:
Suitable for use in ELISA and Western Blot.
Other applications have not been determined.
Recommended Dilutions:
Western Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 6 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot and store at -20 degrees C. Reconstituted product is stable for 1 month at 4 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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