FMIP (E602) pAb

Cat no: BS9167

Supplier: Bioworld Technology, Inc.

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Although the macrophage colony stimulating factor (M-CSF) and its receptor, c-Fms, are involved in the survival and proliferation of hematopoietic cells, little is known about the signalling events leading to differentiation into mature blood cells. A 78 kDa Fms-interacting protein, FMIP, transiently binds to M-CSFactivated Fms-molecules. This binding results in a rapid phosphorylation of FMIP within its Fms-binding domain, thereby dissociating Fms and FMIP. Endogenous levels of FMIP may form a threshold that decide whether bipotential progenitor cells differentiate into macrophages or granulocytes. Myeloid progenitor cells express low levels of endogenous FMIP and, upon M-CSF specific signalling, are differentiated into macrophages. Overexpression of FMIP may saturate Fms, which results in predominant cytoplasmic expression of FMIP and favors granulocyte differentiation.

Catalogue number:	BS9167
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q13769
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 570-624 of Human FMIP.
Species:	FMIP (E602) pAb detects endogenous levels of FMIP protein.
Molecular weight:	~ 78 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	C22orf19; Chromosome 22 open reading frame 19; Fmip; Fms interacting protein; fSAP79; Functional spliceosome-associated protein 79; LOC400922; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; THO complex 5;
Additional info:	For research use only, not for use in diagnostic procedure.

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FMIP (E602) pAb

Cat no: BS9167

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