FMIP (E602) pAb

Although the macrophage colony stimulating factor (M-CSF) and its receptor, c-Fms, are involved in the survival and proliferation of hematopoietic cells, little is known about the signalling events leading to differentiation into mature blood cells. A 78 kDa Fms-interacting protein, FMIP, transiently binds to M-CSFactivated Fms-molecules. This binding results in a rapid phosphorylation of FMIP within its Fms-binding domain, thereby dissociating Fms and FMIP. Endogenous levels of FMIP may form a threshold that decide whether bipotential progenitor cells differentiate into macrophages or granulocytes. Myeloid progenitor cells express low levels of endogenous FMIP and, upon M-CSF specific signalling, are differentiated into macrophages. Overexpression of FMIP may saturate Fms, which results in predominant cytoplasmic expression of FMIP and favors granulocyte differentiation.

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SPECIFICATIONS

Catalog Number

BS9167

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 570-624 of Human FMIP.

Species

FMIP (E602) pAb detects endogenous levels of FMIP protein.

Dilutions

WB: 1:500~1:1000\r\nIHC: 1:50~1:200

Swiss Prot

Q13769

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 78 kDa

Alternative Names

C22orf19; Chromosome 22 open reading frame 19; Fmip; Fms interacting protein; fSAP79; Functional spliceosome-associated protein 79; LOC400922; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; THO complex 5;