FMIP (E602) Peptide

Although the macrophage colony stimulating factor (M-CSF) and its receptor, c-Fms, are involved in the survival and proliferation of hematopoietic cells, little is known about the signalling events leading to differentiation into mature blood cells. A 78 kDa Fms-interacting protein, FMIP, transiently binds to M-CSFactivated Fms-molecules. This binding results in a rapid phosphorylation of FMIP within its Fms-binding domain, thereby dissociating Fms and FMIP. Endogenous levels of FMIP may form a threshold that decide whether bipotential progenitor cells differentiate into macrophages or granulocytes. Myeloid progenitor cells express low levels of endogenous FMIP and, upon M-CSF specific signalling, are differentiated into macrophages. Overexpression of FMIP may saturate Fms, which results in predominant cytoplasmic expression of FMIP and favors granulocyte differentiation.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS9167P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide FMIP (E602). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q13769

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS9167 FMIP (E602) pAb.

Alternative Names

C22orf19; Chromosome 22 open reading frame 19; Fmip; Fms interacting protein; fSAP79; Functional spliceosome-associated protein 79; LOC400922; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; THO complex 5;