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FMN2 (Formin-2)

FMN2 (Formin-2)

Cat no: F5385-01

Supplier: United States Biological
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FMN2 is a protein belonging to the Formin homology family and Cappuccino subfamily (due to their high homology to the Drosophila 'cappuccino' protein). An FH1 domain with 11 proline repeats and a FH2 domain are conserved in both FMN1 and FMN2. It plays an important role in cytoskeletal organization and/or establishment of cell polarity. FMN2 may also be involved in maintenance of the meiotic spindle. Reports suggest that upon DNA damage, FMN2 gets phosphorylated by ATM or ATR. Northern blot analysis revealed the expression of FMN2 exclusively in both developing and mature central nervous system tissues. It is expressed in various human tumors, including parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.25-0.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F5385-01
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Matsuoka, S. et al. Science. 316:1160-1166 (2007). 2. Leader, B. et al. Mech. Dev. 93:221-231 (2000). 3. Leader, B. et al. Nature Cell Biol. 4:921-928 (2002).
Additional info: Recognizes human FMN2. Species sequence homology: mouse.

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