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Follicular Dendritic Cells

Follicular Dendritic Cells

Cat no: F5923-50

Supplier: United States Biological
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Follicular dendritic cells (FDC) are cells of the immune system found in lymph follicles of secondary lymphoid organs and tertiary lymphoid organs. They are probably not of hematopoietic origin, though they look similar to true dendritic cells due to their filiform dendritic processes, but are of stromal, mesenchymal origin. The term FDC was introduced to distinguish them from other stromal cells localizing in the B cell follicles, the reticular fibroblast cells. FDCs are originally defined as cells within lymphoid follicles, which trap immune complexes. Their classification in MeSH. They assist in B cell maturation by the presentation of intact antigen to the B cells. This occurs in the germinal centers of peripheral lymphoid organs and induces class switching and proliferation. Applications: Suitable for use in Immunohistochemistry (frozen). Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:260 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F5923-50
Reactivities: Rat
Hosts: Mouse
Applications: Immunohistochemistry
Size: 250ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Jeurissen, S.H.M & Dijkstra, C.D. (1986) Characteristics and functional aspects of non lymphoid cells in rat germinal centres, recognised by two monoclonal antibodies ED5 and ED6. Eur. J. Immunol. 16: 562-568. General References: 1. Liu Y, Grouard G, de Bouteiller O, Banchereau J (1996). "Follicular dendritic cells and germinal centers". Int Rev Cytol 166: 139
Additional info: Recognizes rat ED5. Does not react with mouse. ED5 staining reveals a web-like pattern in B cell follicles, representing the follicular dendritic cells. Mesangial cells in the kidney are also ED5-positive.

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