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Follicular Dendritic Cells

Follicular Dendritic Cells

Cat no: F5923-51

Supplier: United States Biological
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Follicular dendritic cells (FDC) are cells of the immune system found in lymph follicles of secondary lymphoid organs and tertiary lymphoid organs. They are probably not of hematopoietic origin, though they look similar to true dendritic cells due to their filiform dendritic processes, but are of stromal, mesenchymal origin. The term FDC was introduced to distinguish them from other stromal cells localizing in the B cell follicles, the reticular fibroblast cells. FDCs are originally defined as cells within lymphoid follicles, which trap immune complexes. Their classification in MeSH. They assist in B cell maturation by the presentation of intact antigen to the B cells. This occurs in the germinal centers of peripheral lymphoid organs and induces class switching and proliferation. Applications: Suitable for use in Immunohistochemistry (frozen and paraffin). Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 0.4ug/ml Immunohistochemistry (paraffin): 2ug/ml Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F5923-51
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 200ug
Form: Supplied as a lyophilized powder from PBS, 0.01% Kathon, 5mg/ml BSA. Reconstitute with 500ul sterile 40-50% glycerol, ddH2O.
P type: Mab
Isotype: IgG1
Purity: Purified by immunoaffinity chromatography.
References: 1. Jeurissen, S.H.M & Dijkstra, C.D. (1986) Characteristics and functional aspects of non lymphoid cells in rat germinal centres, recognised by two monoclonal antibodies ED5 and ED6. Eur. J. Immunol. 16: 562-568. General References: 1. Liu Y, Grouard G, de Bouteiller O, Banchereau J (1996). "Follicular dendritic cells and germinal centers". Int Rev Cytol 166: 139
Additional info: Recognizes human Follicular Dendritic Cells.

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