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FOLR3 (folate receptor 3, FRg, FOLBP-3)

Cat no: F5750-18

FOLR3 (folate receptor 3, FRg, FOLBP-3)

FOLR3 (folate receptor 3; also FR-g and FOLBP-3) is a 32kD, secreted member of the folate receptor family. Although folate family receptors can internalize folate, they are generally not the principal conduits for folate uptake. FOLR3 will bind folate in milk and blood, possibly stabilizing this molecule. Its levels are low, however, and it is best known as a potential marker for malignancy. Human FOLR3 contains a 23aa signal sequence and a 220aa mature region. There are no definitive structural motifs. There is one isoform that shows a premature truncation after Leu104. This does not bind folate. A second isoform shows a 53aa substitution for aa1-105. No definitive mouse counterpart to human FLOR3 has been reported. \n\nApplications:\nSuitable for use in Direct ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 2ug/ml. Using human spleen tissue\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F5750-18

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human FOLR3. In Direct ELISAs, 10% crossreactivity with rhFLOR2 is observed and no crossreactivity with rhFLOR4.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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