FOLR3 (folate receptor 3; also FR-g and FOLBP-3) is a 32kD, secreted member of the folate receptor family. Although folate family receptors can internalize folate, they are generally not the principal conduits for folate uptake. FOLR3 will bind folate in milk and blood, possibly stabilizing this molecule. Its levels are low, however, and it is best known as a potential marker for malignancy. Human FOLR3 contains a 23aa signal sequence and a 220aa mature region. There are no definitive structural motifs. There is one isoform that shows a premature truncation after Leu104. This does not bind folate. A second isoform shows a 53aa substitution for aa1-105. No definitive mouse counterpart to human FLOR3 has been reported.
Applications:
Suitable for use in Direct ELISA and Western Blot. Other applications not tested.
Recommended Dilutions:
Western Blot: 2ug/ml. Using human spleen tissue
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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