Home  >  Products  >  Formin Binding Protein 1 (Formin-binding Protein 1, FBP1, FNBP1, Formin Binding Protein 17, FBP17, hFBP17, KIAA0554, MGC126804)
Formin Binding Protein 1 (Formin-binding Protein 1, FBP1, FNBP1, Formin Binding Protein 17, FBP17, hFBP17, KIAA0554, MGC126804)

Formin Binding Protein 1 (Formin-binding Protein 1, FBP1, FNBP1, Formin Binding Protein 17, FBP17, hFBP17, KIAA0554, MGC126804)

Cat no: F6002-62A

Supplier: United States Biological
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FNBP1 is a regulatory protein belonging to the formin-binding-protein family. It has a FCH domain, a coiled-coil domain, a Rho family protein-binding domain (RBD), and a SH3 domain. FNBP1 interacts with sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin and is an important regulator of endocytosis. It self associates and binds to lipids to promote membrane invagination and the formation of tubules. It acts as a link between RND2 signaling and regulation of the actin cytoskeleton. FNBP1 induces neurite branching in response to ARHN. The MLL-FNBP1 fusion protein with MLL has very low transforming ability. FNBP1 is associated with acute myelogemous leukemia. FNBP1 is very highly expressed in epithelial cells, brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon-producing cells of the pancreas, germ cells of the testis and brain. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human liver lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6002-62A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Fuchs, U. et al. Nat. Acad. Sci. 98:8756-8761 (2001). 2. Shimada, A. et al. Cell. 129:761-772 (2007). 3. Fuchs, U. et al. FEBS. Lett. 554:10-16 (2003).
Additional info: Recognizes human FNBP1. Species Crossreactivity: mouse and rat. Species sequence homology: pufferfish, rabbit, xenopus, zebrafish.

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