Formin Binding Protein 1 (Formin-binding Protein 1, FBP1, FNBP1, Formin Binding Protein 17, FBP17, hFBP17, KIAA0554, MGC126804)

FBP17, a 71kD microtubule binding protein, is a member of Formin binding protein family. It consists of a CIP4 homology (FCH) domain at the N-terminus, followed by first coiled-coil domain, a proline rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBP) and a C-terminal SH3 domain. FBP17 binds to dynamin with its FCH domain and induces tubular membrane invaginations thereby participating in dynamin-mediated endocytosis. It also interacts with Rho family GTPases and Snx2, a protein involved in EGFR signaling and plays a significant role during cytoskeleton organization, cell polarity and signal transduction.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.25-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman Testis lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F6002-62B

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N.A novel dynamin-associatingFNB molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.J Biol Chem. 2004 Sep 17;279(38):40091-9. Epub 2004 Jul 12. PMID: 15252009. 2. U Fuchs et.al, PNAS, 98(15) 8756-8761 (July 17, 2001). 3. Katoh M, et.al. Int. J. Mol. Med. 13 (1): 157-62 (2004 Jan).

Additional Info

Recognizes human FBP17. Species sequence homology: mouse and rat.