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FOXC1 (Forkhead Box Protein C1, Forkhead-related Protein FKHL7, Forkhead-related Transcription Factor 3, FREAC-3, FKHL7, FREAC3)

FOXC1 (Forkhead Box Protein C1, Forkhead-related Protein FKHL7, Forkhead-related Transcription Factor 3, FREAC-3, FKHL7, FREAC3)

Cat no: F9045-49E

Supplier: United States Biological
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FOXC1 is a protein belonging to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this protein is not known, however, it plays a role in the regulation of FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. Mutations in this gene cause various glaucoma, iridogoniodysgenesis anomaly, Peters anomaly that includes central corneal leukoma, absence of the posterior corneal stroma and Descemetmembrane and Axenfeld-Rieger anomaly characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth and mental retardation. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:250-1:1000 Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Positive Control: Human liver lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F9045-49E
Reactivities: Human, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 200ul
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Fuse, N. et al. Mol. Vis. 13:1005-1009 (2007). 2. Berry, FB. et al. J. Biol. Chem. 281:10098-10104 (2006). 3. Tamimi, Y. et al. Hum. Mol. Genet. 15:3229-3240 (2006).
Additional info: Recognizes human FOXC1. Species Crossreactivity: monkey. Species sequence homology: bovine, mouse, rat.

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