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FoxJ1 (T295) pAb

FoxJ1 (T295) pAb

Cat no: BS2116

Supplier: Bioworld Technology, Inc.
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Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and thus spontaneous autoimmunity, through the repression of NF?B activity. FOXJ1 also inhibits the humoral immune response in B cells; FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation, implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.
Catalogue number: BS2116
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q92949
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 264-315 of Human FoxJ1.
Species: FoxJ1 (T295) pAb detects endogenous levels of FoxJ1 protein.
Molecular weight: ~ 58 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: FKHL13; forkhead box J1; Fox J1; FoxJ1; HFH 4; HFH-4; HFH4;
Additional info: For research use only, not for use in diagnostic procedure.

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