FoxJ1 (T295) pAb

Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and thus spontaneous autoimmunity, through the repression of NF?B activity. FOXJ1 also inhibits the humoral immune response in B cells; FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation, implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.

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SPECIFICATIONS

Catalog Number

BS2116

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 264-315 of Human FoxJ1.

Species

FoxJ1 (T295) pAb detects endogenous levels of FoxJ1 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

Q92949

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul