Frizzled-2 (E240) Peptide

Cat no: BS3163P

Supplier: Bioworld Technology, Inc.

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The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-XXX-Val motif. The proteins in this family function as receptors for Wnt and are generally coupled to G proteins. Frizzleds are members of the G protein-coupled receptor superfamily. Frizzled-2 is expressed in the fetal kidney and lung and in the adult ovary and colon. Frizzled-2 mediates the Wnt/cGMP/Ca2+ pathway. It binds Wnt proteins and signals by activating the release of stored calcium. Frizzled-2 expression is regulated by Angiotensin II. Activated frizzled-2 suppresses the activity of protein kinase G, and activates NFAT-dependent transcription, the phosphatidylinositol pathway and calcium sensitive enzymes.

Catalogue number:	BS3163P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q14332
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Frizzled-2 (E240). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Fz-2; hFz2; FzE2; FZD2
Additional info:	This peptide can be used with studies using BS3163 Frizzled-2 (E240) pAb.

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Frizzled-2 (E240) Peptide

Cat no: BS3163P

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