Frizzled-8 (K528) Peptide

Cat no: BS2715P

Supplier: Bioworld Technology, Inc.

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The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins (FRPs), have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The cysteine-rich domain of frizzled-8 blocks endogenous Wnts and the effects of Wnt-1 and Wnt-5 on proliferation. The mouse frizzled-8 gene, which encodes a Wnt receptor, is a potent cancer-associated activator of the beta-catenin-TCF pathway. The frizzled-8 gene contains no introns. Frizzled-8 mRNA has been detected in fetal brain and kidney, and also in adult pancreas, skeletal muscle, kidney and heart. Frizzled is highly expressed in HeLa S3 (cervical uterus cancer) cells and A549 lung cancer cells.

Catalogue number:	BS2715P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q9H461
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Frizzled-8 (K528). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Fz-8; hFz8; FZD8; FZ-8; Hfz8
Additional info:	This peptide can be used with studies using BS2715 Frizzled-8 (K528) pAb.

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Frizzled-8 (K528) Peptide

Cat no: BS2715P

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