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Frizzled-9 (L591) Peptide

Frizzled-9 (L591) Peptide

Cat no: BS2775P

Supplier: Bioworld Technology, Inc.
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The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The frizzled-9 gene is located within the Williams Syndrome common deleted region at chromosomal band 7q11.23. Heterozygous deletion of the frizzled-9 gene may contribute to the Williams Syndrome phenotype. In mouse, frizzled-9 overexpression can induce the hyperphosphorylation and relocalization of Dvl-1 from the cytoplasm to the cell membrane and cytosolic beta-catenin accumulation. In rat, frizzled-9 is important in Wnt/beta-catenin signaling in 293T cells. Frizzled-9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.
Catalogue number: BS2775P
Applications: Block/Neutralize/Inhibit
Swiss prot: O00144
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Frizzled-9 (L591). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Frizzled9; Frizzled 9; Frizzled3; Frizzled 3; Frizzled-3;Fz-9; hFz9; FzE6; CD349; FZD9; FZD3
Additional info: This peptide can be used with studies using BS2775 Frizzled-9 (L591) pAb.

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