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FXR2 (E576) Peptide

FXR2 (E576) Peptide

Cat no: BS2008P

Supplier: Bioworld Technology, Inc.
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Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene, and in the fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 can also interact with two fragile X syndrome related factors, FXR1 and FXR2, and these proteins form heterodimers through their N-terminal coilcoiled domains. FMR1 localizes to both the nucleus and the cytoplasm, and since it contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleo-cytoplasmic transport of mRNAs.
Catalogue number: BS2008P
Applications: Block/Neutralize/Inhibit
Swiss prot: P51116
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide FXR2 (E576). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Fragile X mental retardation syndrome-related protein 2; FMR1L2; FXR2
Additional info: This peptide can be used with studies using BS2008 FXR2 (E576) pAb.

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