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G(alpha) t1 (M104) pAb

G(alpha) t1 (M104) pAb

Cat no: BS3311

Supplier: Bioworld Technology, Inc.
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Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e. adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein (alpha), (beta) and (gamma) polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their (alpha) subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G(alpha) subunits have been identified; these include Gs, Gi, Gq and G(alpha) 12/13. The Gi class comprises all the known (alpha) subunits that are susceptible to pertussis toxin modifications, including G(alpha) i-1, G(alpha) i-2, G(alpha) i-3, G(alpha) o, G(alpha) t1, G(alpha) t2, G(alpha) z and G(alpha) gust. In the well characterized visual system, photorhodopsin catalyzes the exchange of guanine nucleotides bound to the visual transducin G(alpha) subunits (G(alpha) t1 in rod cells and G(alpha) t2 in cone cells).
Catalogue number: BS3311
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P11488
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 71-120 of Human G(alpha) t1.
Species: G(alpha) t1 (M104) pAb detects endogenous levels of G(alpha) t1 protein.
Molecular weight: ~ 36 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Guanine nucleotide-binding protein G(t) subunit alpha-1; Transducin alpha-1 chain; GNAT1; GNATR; Transducin (alpha)-1; Transducin (alpha)1; G(alpha)t1; G(alpha)-t1
Additional info: For research use only, not for use in diagnostic procedure.

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