Gab 2 (R270) Peptide

Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major Insulin receptor substrate. Shc and Gab 1 also participate in Insulin signaling by linking the Insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. The Gap 1 related protein, Gab 2, associates with SH2 domain-containing proteins, such as SHP2, and it is involved in a novel pathway for cytokine-induced gene activation.

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SPECIFICATIONS

Catalog Number

BS9263P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Gab 2 (R270). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9UQC2

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS9263 Gab 2 (R270) pAb.

Alternative Names

GAB 2; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; Growth factor receptor bound protein 2 associated protein 2; KIAA0571; p97; PH domain containing adaptor molecule p97; pp100;