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Gab1 (G621) Peptide

Cat no: BS3654P

Gab1 (G621) Peptide

Gab 1 (GRB2-associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi-substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3- kinase (PI3K) binding. In response to osmotic shock, tyrosine-phosphorylated Gab 1 (p-Gab 1) also binds and activates phosphatidylinositol 3-kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.

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SPECIFICATIONS

Catalog Number

BS3654P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Gab1 (G621). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q13480

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3654 Gab1 (G621) pAb.

Alternative Names

GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1; GAB1

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