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Gads (N158) pAb

Gads (N158) pAb

Cat no: BS3870

Supplier: Bioworld Technology, Inc.
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In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-(gamma), within structural proteins, such as spectrin or myosin, and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids that bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. Deletion or mutation of SH3 domains generally activates the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. Gads is an adapter proteins that contains both SH2 and SH3 domains. Gads binds to tyrosine-phosphorylated proteins, such as Shc, and functions to couple these proteins to downstream effectors.
Catalogue number: BS3870
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O75791
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 131-180 of Human Gads.
Species: Gads (N158) pAb detects endogenous levels of Gads protein.
Molecular weight: ~ 38 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: DCE 2; DCE 2; DCE2; DCE2; GAD 2; GAD 2; GAD 65; GAD 65; GAD-2; GAD-2; GAD-65; GAD-65; GAD2; GAD2; Glutamate Decarboxylase 2; Glutamate Decarboxylase 2; Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa); Glutamate Decarboxylase 2 (pancreat
Additional info: For research use only, not for use in diagnostic procedure.

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