Gastrin (M90)Peptide

Cat no: BS1139P

Supplier: Bioworld Technology, Inc.

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Gastrin, which is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, is a hormone whose main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Gastrin also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger- Ellison syndrome. Gastrin maps to human chromosome 17q-21. Gastrin- Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones, in addition to acting as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems and, interestingly, is induced by retinoic acid.

Catalogue number:	BS1139P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P01350
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Gastrin (M90). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Gastrin prediluted; Gastrin; Big gastrin. GAS. GAST. Gastrin precursor.
Additional info:	This peptide can be used with studies using BS1139 Gastrin (M90)pAb.

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Gastrin (M90)Peptide

Cat no: BS1139P

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