GATA2/3 (K304) Peptide

Cat no: BS1646P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

Catalogue number:	BS1646P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P23771/P23769
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide GATA2/3 (K304). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	GATA-binding factor 3; GATA3; 2625; GATA3; 131320; P23771; HDR; MGC2346; MGC5199; MGC5445;
Additional info:	This peptide can be used with studies using BS1646 GATA2/3 (K304) pAb.

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GATA2/3 (K304) Peptide

Cat no: BS1646P

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