GCP4 (L225) pAb

The (gamma)-Tubulin complex is composed of (gamma) Tubulin and the (gamma)-Tubulin complexassociated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. (gamma)-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the (gamma)-Tubulin complex. GCP4 ((gamma)-Tubulin complex component 4), also known as TUBGCP4, is a ubiquitously expressed 667 amino acid member of the (gamma)-Tubulin complex that localizes to the metaphase spindle during mitosis. In response to proteosome inhibition, GCP4 exhibits increased accumulation at the pericentiolar material where it participates in microtubule organization and nucleation.

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SPECIFICATIONS

Catalog Number

BS3302

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 197-243 of Human GCP4.

Species

GCP4 (L225) pAb detects endogenous levels of GCP4 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q9UGJ1

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul