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GCS-beta-1 (V21) Peptide

GCS-beta-1 (V21) Peptide

Cat no: BS1158P

Supplier: Bioworld Technology, Inc.
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Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
Catalogue number: BS1158P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q02153
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide GCS-beta-1 (V21). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Guanylate cyclase soluble subunit beta-1; GCS-beta-1; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit; GUCY1B3; GUC1B3; GUCSB3; GUCY1B1; GCS-beta1; GCS beta1; GCSbeta1; GCS-beta3; GCS beta3; GCSbeta3; GCS-beta-3
Additional info: This peptide can be used with studies using BS1158 GCS-beta-1 (V21) pAb.

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