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GCSm-(gamma) (V91) pAb

GCSm-(gamma) (V91) pAb

Cat no: BS2927

Supplier: Bioworld Technology, Inc.
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Gamma-glutamylcysteine synthetase ((gamma)-GCS) is the rate limiting enzyme for glutathione (L-(gamma)-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. (gamma)-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic ntioxidants, heat shock, oxidants and cytokines. The human (gamma)-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human (gamma)-GCS gene encoding the regulatory subunit maps to chromosome 1p22-p21. The two subunits of (gamma)-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.
Catalogue number: BS2927
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P48507
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 50-100 of Human GCSm-(gamma).
Species: GCSm-(gamma) (V91) pAb detects endogenous levels of GCSm-(gamma) protein.
Molecular weight: ~ 30 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit; GLCLR; GCLM
Additional info: For research use only, not for use in diagnostic procedure.

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