GFR(alpha)-1 (K90) pAb

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF(beta) superfamily of growth factors. Three receptors for these factors, GFR(alpha)-1 (also designated GDNFR-(alpha), RETL1 or TrnR-1), GFR(alpha)-2 (also designated GDNFR-(beta), RETL2, NTNR-(alpha) or TrnR-2) and GFR(alpha)-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFR(alpha)-1 and GFR(alpha)-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR(alpha)-3 is expressed only during development.

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SPECIFICATIONS

Catalog Number

BS1141

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 50-100 of Human GFR(alpha)-1.

Species

GFR (alpha)-1 (K90) pAb detects endogenous levels of GFR (alpha)-1 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P56159

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 51 kDa

Alternative Names

GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GFRA1; GDNFRA; RETL1; TRNR1; GFR(alpha)1; GFR (alpha)1; GFR (alpha)-1; GFR (alpha)1