GFR(alpha)-4 (P178) pAb

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFR(alpha)-1 (previously designated GDNFR-(alpha)), GFR(alpha)-2 (also designated RETL2), GFR(alpha)-3 and GFR(alpha)-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFR(alpha)-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

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SPECIFICATIONS

Catalog Number

BS3304

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 148-195 of Human GFR(alpha)-4.

Species

GFR(alpha)-4 (P178) pAb detects endogenous levels of GFR(alpha)-4 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q9GZZ7

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul