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Glucosidase II(beta) (K117) pAb

Glucosidase II(beta) (K117) pAb

Cat no: BS2646

Supplier: Bioworld Technology, Inc.
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Trimming of glucoses from N-linked core glycans on newly synthesized glycoproteins occurs sequentially through the action of Glucosidases I and II in the endoplasmic reticulum (ER). Glucosidase II is an ER-localized enzyme that contains (alpha) and (beta) subunits (Glucosidase II(alpha) and Glucosidase II(beta)). The (alpha) and (beta) subunits form a defined heterodimeric complex with a molecular weight about 161 kDa. Glucosidase II(alpha) is the catalyitc core of the enzyme and can function independently of the (beta) subunit. The sequence of Glucosidase II(beta) encodes protein rich in glutamic and aspartic acid with a putative ER retention signal (HDEL) at the C terminus. The phosphorylated form of Glucosidase II(beta) is localized in the plasma membrane and is highly expressed in FGF stimulated fibroblasts and epidermal carcinoma cells. Glucosidase II(beta) was first purified from a human carcinoma cell line as a potential substrate for protein kinase C. Through the HDEL signal at the C-terminus, Glucosidase II(beta) retains the complete complex in the ER.
Catalogue number: BS2646
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 100ug/100ul
Swiss prot: P14314
Dilutions: WB: 1:500~1:1000 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 90-130 of Human Glucosidase II(beta).
Species: Glucosidase II(beta) (K117) pAb detects endogenous levels of Glucosidase II(beta) protein.
Molecular weight: ~ 59 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: PRKCSH; G19P1; PKCSH; 80K-H protein; Glucosidase 2 subunit beta
Additional info: For research use only, not for use in diagnostic procedure.

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