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Glucosidase IIbeta (K117) Peptide

Glucosidase IIbeta (K117) Peptide

Cat no: BS2646P

Supplier: Bioworld Technology, Inc.
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Trimming of glucoses from N-linked core glycans on newly synthesized glycoproteins occurs sequentially through the action of Glucosidases I and II in the endoplasmic reticulum (ER). Glucosidase II is an ER-localized enzyme that contains alpha and beta subunits (Glucosidase IIalpha and Glucosidase IIbeta). The alpha and beta subunits form a defined heterodimeric complex with a molecular weight about 161 kDa. Glucosidase IIalpha is the catalyitc core of the enzyme and can function independently of the beta subunit. The sequence of Glucosidase IIbeta encodes protein rich in glutamic and aspartic acid with a putative ER retention signal (HDEL) at the C terminus. The phosphorylated form of Glucosidase IIbeta is localized in the plasma membrane and is highly expressed in FGF stimulated fibroblasts and epidermal carcinoma cells. Glucosidase IIbeta was first purified from a human carcinoma cell line as a potential substrate for protein kinase C. Through the HDEL signal at the C-terminus, Glucosidase IIbeta retains the complete complex in the ER.
Catalogue number: BS2646P
Applications: Block/Neutralize/Inhibit
Swiss prot: P14314
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Glucosidase IIbeta (K117). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: PRKCSH; G19P1; PKCSH; 80K-H protein; Glucosidase 2 subunit beta
Additional info: This peptide can be used with studies using BS2646 Glucosidase IIbeta (K117) pAb.

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