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GluR-(delta)2 (G860) pAb

GluR-(delta)2 (G860) pAb

Cat no: BS3029

Supplier: Bioworld Technology, Inc.
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Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR-(delta)2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: E1, 2, 3, 4 and one (zeta)subunit. The (zeta)subunit is expressed throughout the brainstem whereas the four E subunits display limited distribution. In mice, mutations in the gene encoding GluR-(delta)2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR-(delta)2 maps to chromosome 4q22.
Catalogue number: BS3029
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 100ug/100ul
Swiss prot: O43424
Dilutions: WB: 1:500~1:1000 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 831-880 of Human GluR-(delta)2.
Species: GluR-(delta)2 (G860) pAb detects endogenous levels of GluR-(delta)2 protein.
Molecular weight: ~ 113 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: GRID2; GLURD2; GluD2; GluR delta-2 subunit; Glutamate receptor ionotropic; delta-2
Additional info: For research use only, not for use in diagnostic procedure.

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