GnRH I (D43) pAb

Human reproduction is controlled by the hypothalaic-pituitary gonadal axislaid down early in fetal development. Luteinizing hormone releasing hormone\n(LHRH), also known as gonadotropin releasing hormone (GnRH), luliberin, gonadorelin or GnRH-associated peptide, is a decapeptide that is an important molecule in the hypothalamic-pituitary-gonadal axis control circuit. GnRH is produced by hypothalamic neurons and secreted in a pulsatile manner into the capillary plexus of the median eminence. GnRH affects the release of lutenizing hormone and follicle stimulating hormone from gonadotropic cells in the anterior pituitary. In addition to hypothalamic GnRH (GnRH I), a second GnRH form (GnRH II) functions primarily in the midbrain. GnRH is xpressed in the acrosomal region of human sperm and in the anterior pituitary tissue and cancer cells. Unlike GnRH I, GnRH II is highly expressed outside the brain,\nparticularly in the kidney, bone marrow and prostate, suggesting that it may have multiple functions. GnRH binds to a specific G protein-coupled receptor in the pituitary to regulate synthesis and secretion of gonadotropins.

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SPECIFICATIONS

Catalog Number

BS2880

Size

100ug/100ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 11-60 of Human GnRH I.

Species

GnRH I (D43) pAb detects endogenous levels of GnRH I protein.

Dilutions

IHC: 1:50~1:200

Swiss Prot

P01148

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul