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GnRH I (D43) pAb

GnRH I (D43) pAb

Cat no: BS2880

Supplier: Bioworld Technology, Inc.
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Human reproduction is controlled by the hypothalaic-pituitary gonadal axislaid down early in fetal development. Luteinizing hormone releasing hormone (LHRH), also known as gonadotropin releasing hormone (GnRH), luliberin, gonadorelin or GnRH-associated peptide, is a decapeptide that is an important molecule in the hypothalamic-pituitary-gonadal axis control circuit. GnRH is produced by hypothalamic neurons and secreted in a pulsatile manner into the capillary plexus of the median eminence. GnRH affects the release of lutenizing hormone and follicle stimulating hormone from gonadotropic cells in the anterior pituitary. In addition to hypothalamic GnRH (GnRH I), a second GnRH form (GnRH II) functions primarily in the midbrain. GnRH is xpressed in the acrosomal region of human sperm and in the anterior pituitary tissue and cancer cells. Unlike GnRH I, GnRH II is highly expressed outside the brain, particularly in the kidney, bone marrow and prostate, suggesting that it may have multiple functions. GnRH binds to a specific G protein-coupled receptor in the pituitary to regulate synthesis and secretion of gonadotropins.
Catalogue number: BS2880
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug/100ul
Swiss prot: P01148
Dilutions: IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 11-60 of Human GnRH I.
Species: GnRH I (D43) pAb detects endogenous levels of GnRH I protein.
Molecular weight: ~ 11 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Progonadoliberin I; Progonadoliberin-1; GNRH; GRH; LHRH; GNRH1
Additional info: For research use only, not for use in diagnostic procedure.

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