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GnTalpha4 (H65) Peptide

Cat no: BS3069P

GnTalpha4 (H65) Peptide

Alpha 1,4-N-acetylflucosaminyltransferase (alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H. pylori infected patients, which suggest the involvement of alpha4Gn-T in defense against H. pylori infection.

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SPECIFICATIONS

Catalog Number

BS3069P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide GnTalpha4 (H65). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9UNA3

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3069 GnTalpha4 (H65) pAb.

Alternative Names

Alpha-1;4-N-acetylglucosaminyltransferase; alpha4GnT; A4GNT; GnTalpha4; alpha4 GnT

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