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GPR105 Peptide

Cat no: BS5738P

GPR105 Peptide

G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR105, also designated P2Y14, is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregulated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modulating peripheral and neuroimmune function.

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SPECIFICATIONS

Catalog Number

BS5738P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide GPR105. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q15391

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5738 GPR105 pAb.

Alternative Names

P2Y purinoceptor 14; P2Y14; G-protein coupled receptor 105; UDP-glucose receptor; P2RY14; KIAA000

SUPPLIER INFO

Bioworld Technology, Inc.

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