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Products GPx4 Polyclonal Antibody
| Catalogue number: | 10005258 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human GPx4 amino acids 81-93 (TQLVDLHARYAEC) |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Phospholipid hydroperoxide glutathione peroxidase (GPx4 or PhGPx) is one of four characterized selenium-dependent glutathione peroxidases. GPx4 is found primarily in the testis where it functions both to protect membrane phospholipids from oxidation in spermatids and as an insoluble structural protein in mature spermatozoa. Three different post-translational forms of GPx4 have been characterized: mitochondrial, non-mitochondrial, and sperm nuclei specific selenoprotein (SnGPx).3 These monomeric GPx4 types migrate to 23, 20, and 34 kDa respectively. GPx4 also forms a 69 kDa homotetramer. Cayman Chemical's GPx4 polyclonal antibody can be used for western blot analysis of GPx4 on samples from murine, rat, and porcine, detecting both 20 kDa and 69 kDa bands. Sequence homology of the peptide antigen with that from other species indicates that the antibody is also expected to work on samples from human, bovine, canine, and chicken. Other applications for use of this antibody have not yet been tested. |
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