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GR (L224) Peptide

Cat no: BS1401P

GR (L224) Peptide

The glucocorticoid receptor (GR) is an ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GRalpha. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis and cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the nonligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

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SPECIFICATIONS

Catalog Number

BS1401P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide GR (L224). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P04150

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1401 GR (L224) pAb.

Alternative Names

GCCR; GCR; GCR; Glucocorticoid receptor; Glucocorticoid receptor lymphocyte; GR; GRL; Grl1; NR3C1; Nuclear receptor subfamily 3 group C member 1;

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