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GRK 2 (D635) pAb

GRK 2 (D635) pAb

Cat no: BS1963

Supplier: Bioworld Technology, Inc.
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Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of (beta)-adrenergic receptor kinase, GRK 2 ((beta)ARK, (beta)ARK1) and GRK 3 ((beta)ARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Catalogue number: BS1963
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P25098
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 600-650 of Human GRK2.
Species: GRK 2 (D635) pAb detects endogenous levels of GRK 2 protein.
Molecular weight: ~ 80 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Beta-adrenergic receptor kinase 1; Beta-ARK-1; (beta)-ARK-1; ARK-(beta)1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1; GRK2; ARK (beta)1; ARK(beta)1; (beta)-ARK1
Additional info: For research use only, not for use in diagnostic procedure.

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