GRK 2 (D635) Peptide

Cat no: BS1963P

Supplier: Bioworld Technology, Inc.

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Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of beta-adrenergic receptor kinase, GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Catalogue number:	BS1963P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P25098
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide GRK 2 (D635). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Beta-adrenergic receptor kinase 1; Beta-ARK-1; beta-ARK-1; ARK-beta1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1; GRK2; ARK beta1; ARKbeta1; beta-ARK1
Additional info:	This peptide can be used with studies using BS1963 GRK 2 (D635) pAb.

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GRK 2 (D635) Peptide

Cat no: BS1963P

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