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GRK1 (A17) pAb

GRK1 (A17) pAb

Cat no: BS3251

Supplier: Bioworld Technology, Inc.
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Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1(alpha) and (beta)); two forms of (beta)-adrenergic receptor kinase: GRK 2 ((beta)ARK, (beta)ARK1) and GRK 3 ((beta)ARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Catalogue number: BS3251
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q15835
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the N-terminal of Human GRK1.
Species: GRK1 (A17) pAb detects endogenous levels of GRK1 protein.
Molecular weight: ~ 63 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Rhodopsin kinase; RK; EC=2.7.11.14; G protein-coupled receptor kinase 1; RHOK; GRK1
Additional info: For research use only, not for use in diagnostic procedure.

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