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GRK5 (Q382) Peptide

GRK5 (Q382) Peptide

Cat no: BS1981P

Supplier: Bioworld Technology, Inc.
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Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of b-adrenergic receptor kinase: GRK 2 (bARK, bARK1) and GRK 3 (bARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Catalogue number: BS1981P
Applications: Block/Neutralize/Inhibit
Swiss prot: P34947
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide GRK5 (Q382). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: G-protein-coupled receptor kinase 5
Additional info: This peptide can be used with studies using BS1981 GRK5 (Q382) pAb.

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