Gross Cystic Disease Fluid Protein 15 (GCDFP-15, PIP, Prolactin-induced protein, HGNC:8993, GCDFP-15, GCDFP15, GP17, GPIP4, Prolactin-inducible protein, Gross cystic disease fluid protein 15)

Gross cystic disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15kD monomer protein, GCDFP 15. The cells within the body that produce GCDFP 15 appear to be restricted primarily to those with apocrine function. Studies have found GCDFP 15 to be a highly specific and sensitive marker for breast cancer.\n\nCellular Localization: Cytoplasmic\n\nApplications: \nSuitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G2023-26D

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Contains Sodium Azide

P Type

Mab

Purity

Tissue culture supernatant

Isotype

IgG2a,k

References

i) Hall et al. British Journal of Cancer 78:360 (1998) ii) Silloo et al. Modern Pathology 11:1038 (1998) iii) Viacava et al. Virchows Arch 432:255 (1998)

Additional Info

This antibody is specific to a 15kD monomer protein called Gross Cystic Disease Fluid Protein 15 (GCDFP 15). Gross cystic disease of the breast is benign premenopausal disorder in which cysts are predominant. These cysts appear to be formed from excessive apocrine cystic secretions, one of which is GCDFP-15. This antibody can be used in for the staining of breast carcinoma, salivary duct carcinoma and apocrine epithelia. Species Crossreactivity: Human.

Alternative Names

PIP, prolactin-induced protein, HGNC:8993, GCDFP-15, GCDFP15, GP17, GPIP4, prolactin-inducible protein, gross cystic disease fluid protein 15