GSK3alpha/beta (G273) Peptide

Cat no: BS1412P

Supplier: Bioworld Technology, Inc.

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Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Catalogue number:	BS1412P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P49840/P49841
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide GSK3alpha/beta (G273). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK3A; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B
Additional info:	This peptide can be used with studies using BS1412 GSK3alpha/beta (G273) pAb.

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GSK3alpha/beta (G273) Peptide

Cat no: BS1412P

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