HAMP pAb

Cat no: BS6803

Supplier: Bioworld Technology, Inc.

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Hepcidin, also known as HAMP, HEPC, LEAP1 or HFE2B, is an 84 amino acid secreted protein that regulates iron-related signaling events. Highly expressed in liver with lower expression in heart, brain, lung, prostate and thyroid, hepcidin is thought to maintain iron homeostasis and, in conjunction with the HFE protein (a protein that is defective in hereditary hemochromatosis), may mediate both iron storage in macrophages and intestinal iron absorption. Additionally, hepcidin has strong antimicrobial activity against gram-positive and gram-negative bacteria, as well as certain yeast strains, suggesting that hepcidin may play a crucial role in staving off bacterial infections. Defects in the gene encoding hepcidin are the cause of hemochromatosis type 2B (also known as juvenile hemochromatosis), an early-onset autosomal recessive disorder that results in severe iron overload and is characterized by hepatic fibrosis, hypogonadotrophic hypogonadism and cardiomyopathy.

Catalogue number:	BS6803
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P81172
Dilutions:	WB: 1:500~1:2000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human HAMP.
Species:	HAMP pAb detects endogenous levels of HAMP protein.
Molecular weight:	~ 9 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Hamp; HEPC; HEPC; Hepc20; Hepc25; HEPCIDIN; Hepcidin 20; Hepcidin 25; Hepcidin antimicrobial peptide; Hepcidin-20; Hepcidin25; HFE2; HFE2B; LEAP 1; LEAP-1; LEAP1; Liver expressed antimicrobial peptide; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor;
Additional info:	For research use only, not for use in diagnostic procedure.

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HAMP pAb

Cat no: BS6803

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