HDAC 9 (P1047) Peptide

Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription.

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SPECIFICATIONS

Catalog Number

BS1168P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide HDAC 9 (P1047). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9UKV0

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1168 HDAC 9 (P1047) pAb.

Alternative Names

Histone deacetylase 9; Short name=HD9; Histone deacetylase 7B; Short name=HD7; Short name=HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR