HDAC4 (N-terminus) mAb

Cat no: MB0041

Supplier: Bioworld Technology, Inc.

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In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, p300/CBP, PCAF (p300/CBPassociated factor), HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.

Catalogue number:	MB0041
Reactivities:	Human
Hosts:	Mouse
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	P56524
Dilutions:	WB: 1:1000 ICC: 1:50~200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids N-terminus of Human HDAC4.
Species:	This antibody detects endogenous levels of HDAC4 (N-terminus) and does not cross-react with related proteins
Molecular weight:	Predicted band size:120KDa Observed band size:130KDa
Purity:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; KIAA0288;
Additional info:	For research use only, not for use in diagnostic procedure.

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HDAC4 (N-terminus) mAb

Cat no: MB0041

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