HDAC8, Recombinant, Human (Active HDAC-8, Recombinat HDAC-8, Human HDAC-8, rh-HDAC-8)

Supplier:

United States Biological

Cat no: 167873

HDAC8, Recombinant, Human (Active HDAC-8, Recombinat HDAC-8, Human HDAC-8, rh-HDAC-8)

Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).\n\nSource:\nRecombinant corresponding to human HDAC8 expressed in insect cells.\n\nMolecular Weight:\n~44kD\n\nBiological Activity:\nActivity of rh-HDAC8 was tested using Arg-His-Lys(Ac)-Lys(Ac)-AFC, a fluorogenic, acetylated peptide based on aa379-382 of p53 as a substrate.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

167873

Size

20ug

Form

Supplied as a liquid in 25mM Tris, pH 7.5, 100mM NaCl, 2.7mM KCl, 3mM MgCl2, 10% glycerol.

Purity

~90% (SDS-PAGE)

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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