Heat Shock Cognate Protein 70, Recombinant, Bovine (HSC70, Heat Shock Protein 73, HSP73) (Biotin)

Supplier:

United States Biological

Cat no: H1830-25B

Heat Shock Cognate Protein 70, Recombinant, Bovine (HSC70, Heat Shock Protein 73, HSP73) (Biotin)

The 70kD heat shock cognate protein, HSC70 is closely related biochemically and biologically to HSP70 and is part of the HSP70 family which contains a number of highly-related protein isoforms ranging in size from 66kD to 78kD. These proteins include both cognate members which are found within major intracellular compartments and highly inducible isoforms which appear to be predominantly cytoplasmic or nuclear in distribution (2). Members of the hsp70 family are molecular chaperones which are involved in many cellular functions such as protein folding, transport, maturation and degradation and they exert their function in an ATP-dependent manner. The molecular chaperones of the HSP70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregration and misfolding and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (3). Recent data has demonstrated that BAG-1 which possesses a ubiquitin-like domain at its amino terminus modulates the chaperone activity of HSC70 and HSP70. These findings reveal a role of BAG-1 as a physical link between the Hsc70/hsp70 chaperone system and the proteasome (4). There is also experimental data which shows that the ATPase domain and the substrate binding domain of HSC70 cooperate and form a cochaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp) which is essential for normal neurotransmitter release (5).\n\nApplications: \nSuitable for use in Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.\n

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SPECIFICATIONS

Catalog Number

H1830-25B

Size

20ug

Conjugates

Biotin

Form

Supplied as a liquid in 10mM sodium phosphate, pH 7.2. Labeled with Biotin.

Purity

(same/more than) 90% as determined by SDS-PAGE analysis.

References

1. Hofmann, K., Wood, S.W., Brinton, C. C. Montibeller, J. A. And Finn, FM.; Proc. Natl. Acad. Sci 77:4666

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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